This continuing medical education self-study monograph, “Management of Acute Hereditary Angioedema: Best Strategies for Emergency Care,” is certified for physicians.
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MEDIUM: MONOGRAPH
Release date: December 15, 2009
CME available until: December 15, 2010
Estimated time to complete this activity: 1 hour
CONTENTS
- Introduction
- History, Disease Description, and Pathophysiology
- Clinical Signs, Diagnosis, and Emergency Management
- Existing and Emerging Treatment Options for Prophylaxis and Acute Attacks
- Conclusion
- References
- Learning Assessment
- Evaluation Form
FACULTY REVIEWERS
Allen P. Kaplan, MD
Clinical Professor of Medicine
Medical University of South Carolina
Charleston, South Carolina
William R. Lumry, MD
Medical Director
AARA Research Center
Dallas, Texas
Marc Riedl, MD, MS
Assistant Professor of Medicine
Section Head, Clinical Immunology and Allergy
University of California, Los Angeles
David Geffen School of Medicine
Los Angeles, California
TARGET AUDIENCE
This activity has been designed to meet the educational needs of physicians involved in the care of adult patients with hereditary angioedema (HAE).
ACTIVITY PURPOSE
This activity is intended to provide physicians with clinical information that will contribute to improving competence in the management of patients with HAE.
STATEMENT OF NEED
Hereditary angioedema (HAE) is an autosomal dominant disease that is estimated to affect 1 in 10,000 to 1 in 50,000 individuals.1 HAE is caused by a functional or quantitative defect in C1 inhibitor.2 During acute attacks, the release of bradykinin results in swelling of the skin, mucosa, intestinal tract, or abdominal viscera.2 Involvement of the upper airway can result in life-threatening asphyxiation; thus, patients at risk for this complication must be monitored carefully for signs of laryngeal edema.2 Traditional adjunctive treatments are typically not efficacious in terminating acute attacks, but new treatments for HAE are on the horizon. In the near future, these new therapies offer hope for overcoming some of the complex treatment and management challenges presented by this multifaceted condition.
1Epstein TG, Bernstein JA. Current and emerging management options for hereditary angioedema in the US. Drugs. 2008;68:2561-2573.
2Nzeako UC, Frigas E, Tremaine WJ. Hereditary angioedema: a broad review for clinicians. Arch Intern Med. 2001;161:2417-2429.
EDUCATIONAL OBJECTIVES
After completing this activity, the participant should be better able to:
- Explain the pathophysiology of hereditary angioedema (HAE)
- Describe key elements of the history and physicial examination of patients with HAE
- Identify therapeutic interventions for acute HAE attacks
- Outline emerging therapies for prophylaxis and acute HAE attacks
DISCLOSURE OF CONFLICTS OF INTEREST
Postgraduate Institute for Medicine (PIM) assesses conflict of interest with its instructors, planners, managers, and other individuals who are in a position to control the content of continuing medical education (CME) activities. All relevant conflicts of interest that are identified are thoroughly vetted by PIM for fair balance, scientific objectivity of studies utilized in this activity, and patient care recommendations. PIM is committed to providing its learners with high-quality CME activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest.
CONTINUING EDUCATION
METHOD OF PARTICIPATION
There are no fees for participating and receiving continuing education (CE) credit for this activity. During the period of December 15, 2009, through December 15, 2010, participants must 1) read the learning objectives and faculty disclosures, 2) study the educational activity, 3) complete the Learning Assessment by recording the best answer to each question in the "Learning Assessment Answers" box on the Evaluation form, 4) complete the Evaluation form, and 5) mail or fax the Evaluation form with the Learning Assessment answers to Postgraduate Institute for Medicine. You may also complete the Learning Assessment online at www.cmeuniversity.com. Click on "Find Post-Test/Evaluation by Course" on the navigation menu, and search by project ID 6455. Upon successfully completing the Learning Assessment and Evaluation form, your certificate will be made available immediately.
Participants must receive a score of at least 70% on the Learning Assessment and must complete and submit the Evaluation form to successfully complete this activity. Participants who successfully complete this activity will be issued a statement of credit via US mail in 4 to 6 weeks.
PHYSICIAN CONTINUING EDUCATION
ACCREDITATION STATEMENT
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through joint sponsorship of Postgraduate Institute for Medicine (PIM) and Robert Michael Educational Institute LLC (RMEI). PIM is accredited by the ACCME to provide continuing medical education for physicians.
CREDIT DESIGNATION
Postgraduate Institute for Medicine designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
STATEMENT OF SUPPORT
This activity is jointly sponsored by Robert Michael Educational Institute LLC and Postgraduate Institute for Medicine, and is supported by an educational grant from ViroPharma Incorporated.
FEE INFORMATION
There is no fee for this educational activity.
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Additional educational activities offered by Robert Michael Educational Institute LLC can be found at www.RMEI.com or by calling toll-free to 866-770-RMEI.
United States Hereditary Angioedema Association
This non-profit patient advocacy organization is dedicated to expediting US approval of safer and more effective HAE therapies. In addition, the HAEA provides a wide range of services that include clinical trial placement, physician referrals, education, and individualized patient case management.
For more information, visit www.haea.org.
